Dr. Hosam Abdelhady, PhDDr. Abdelhady is interested in understanding the mechanisms of the molecular interactions between the pharmacological agents and the biomolecular targets (DNA, RNA, receptor, etc.) that yields therapeutic responses by applying the 4D-single biomolecular and cellular imaging and biomolecular mapping techniques using the state-of-the-art atomic force microscopy in native molecular environment.
Dr. Abdelhady is interested in understanding the mechanisms of the molecular interactions between the pharmacological agents and the biomolecular targets (DNA, RNA, receptor, etc.) that yields therapeutic responses by applying the 4D-single biomolecular and cellular imaging and biomolecular mapping techniques using the state-of-the-art atomic force microscopy in native molecular environment.
Dr. Abdelhady initiated his research career in the Bioavailability center at the National Organization for Drug Quality Control and Research (equivalent to the FDA), in Cairo, Egypt, where he developed the Pharmacokinetics and Biostatistics programs for postgraduate researchers, and was recognized with an excellence award from the Egyptian government.
Dr. Abdelhady received two awards from King Abdulaziz City for Science and Technology (KACST), the main funding institute in KSA, with two large grants to 1-Film Unseen Scenarios of the suicidal effects of novel gene nanoparticles on individual cancer cells, using real-time nanoimaging in native environments and to investigate the effect of natural small molecules on delaying and/or preventing Alzheimer's disease and tau pathology. Due to his achievements in the 4D bioimaging research, he was awarded the Golden Medal of Sciences during the 4th International Workshop on Ultra-Fast Laser Technology and Application in 2012 from Cairo University, Egypt.
Abdelhady H, Aleanizy F, Alqahtani F, Bukhari A, Soliman S, Sau S, Iyer A. Visualizing the 4D Impact of Gold Nanoparticles on DNA. Int J Mol Sci. 2023 Dec 30;25(1):542. doi: 10.3390/ijms25010542. PMID: 38203711.
Mashal Y, Abdelhady H, Iyer AK. Comparison of Tau and Amyloid-β Targeted Immunotherapy Nanoparticles for Alzheimer's Disease. Biomolecules. 2022 Jul 18;12(7):1001. doi: 10.3390/biom12071001. PMID: 35883556.
Ahmar Rauf M, Nisar M, Abdelhady H, Gavande N, Iyer AK. Nanomedicine approaches to reduce cytokine storms in severe infections. Drug Discov Today. 2022 Nov;27(11):103355. doi: 10.1016/j.drudis.2022.103355. Epub 2022 Sep 12. PMID: 36099962; PMCID: PMC9465473.
Rebecca Andrews-Dickert, MDDr. Rebecca Andrews-Dickert’s research has focused on quality of care and clinical decision-making in the assessment and treatment of patients in the emergency care setting. Her research experience includes the assessment and validation of an instrument to measure quality of care provided to children in the Emergency Department. This instrument was then used to evaluate the association of various patient-level, provider-level, and hospital-level factors with process measures of quality of care delivered to pediatric patients in Emergency Departments. An additional area of her research has been the evaluation of an inflammatory biomarker panel consisting of white blood cell (WBC), C-reactive protein (CRP), and myeloid-related protein (MRP) 8/14, and its clinical application to the diagnosis of appendicitis in pediatric patients, with a focus on diagnostic resource utilization and the potential to reduce computerized tomography (CT) ionizing radiation exposure for pediatric patients. Dr. Andrews-Dickert desires to improve patient quality of care through continued research in medical education and clinical decision-making processes, and her areas of research interest at Sam Houston State University College of Osteopathic Medicine include medical education methods, physician decision-making processes, and health care worker career longevity.
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Medical education |
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Pediatric quality of care |
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Physician career longevity and wellness |
Research Highlights |
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Published in: Journal of Academic Emergency Medicine Honors: Site Principal Investigator for Quality of Care study with Pediatric Emergency Care, Applied Research Network (PECARN), 2011 |
Andrews-Dickert R, Nagaraj R, Zhan L, Knittig L, Zhao Y. Improving learning experience through implementing standardized team-based learning process in undergraduate medical education. BMC Med Educ. 2024;24(1):1098. Published 2024 Oct 7. doi:10.1186/s12909-024-06025-6
Marcin JP, Romano PS, Dayal P, Dharmar M, Chamberlain JM, Dudley N, Macias CG, Nigrovic LE, Powell EC, Rogers AJ, Sonnett M, Tzimenatos L, Alpern ER, Andrews-Dickert R, Borgialli DA, Sidney E, Casper TC, Kuppermann N; Pediatric Emergency Care Applied Research Network. Provider-Level and Hospital-Level Factors and Process Measures of Quality Care Delivered in Pediatric Emergency Departments. Acad Pediatr. 2020 May-Jun;20(4):524-531. doi: 10.1016/j.acap.2019.11.007.
Marcin JP, Romano PS, Dayal P, Dharmar M, Chamberlain JM, Dudley N, Macias CG, Nigrovic LE, Powell EC, Rogers AJ, Sonnett M, Tzimenatos L, Alpern ER, Andrews-Dickert R, Borgialli DA, Sidney E, Charles Casper T, Michael Dean J, Kuppermann N; Pediatric Emergency Care Applied Research Network. Patient-level Factors and the Quality of Care Delivered in Pediatric Emergency Departments. Acad Emerg Med. 2018 Mar;25(3):301-309. doi: 10.1111/acem.13347.
Depinet H, Copeland K, Gogain J, Hennes H, Paradis NA, Andrews-Dickert R, Vance CW, Huckins DS; APAB Study Group. Addition of a biomarker panel to a clinical score to identify patients at low risk for appendicitis. Am J Emerg Med. 2016 Dec;34(12):2266-2271. doi: 10.1016/j.ajem.2016.08.018.
Marcos Garza-Madrid, MD PhDDr Garza’s biomedical research interests lie on the interactions between cells and their surrounding environment. Particularly on how to make use of the cellular microenvironment (the extracellular matrix) to affect cells behavior for tissue engineering and biotechnology applications. His early research in hematology and preservation of hematopoietic stem cells paved the way for his interest in environmental control of cellular differentiation. During his doctoral studies Dr. Garza focused on cell sorting and surface modifications for recombinant protein production. His translational post-doctorate research aimed at modifying collagen matrices for ophthalmological applications such as patches and replacement treatment. Dr. Garza is currently establishing research lines in production of self-assembled matrices for cell culture, surface modification for cellular guidance, and tissue engineering. On the medical education front, Dr. Garza is interested in bridging the gaps between curricular design, assessment, and academic success.
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Mihail Mitov, PhDhttps://orcid.org/0000-0001-9101-5053
Dr. Mitov received a M.Sc. in Biology and earned a Ph.D. from the Bulgarian Academy of Science after completing graduate research focused on novel physiological approaches for treatment of parasitic infections. Fascinated by the scientific approach to understand how the human body works, Dr. Mitov pursued his postdoctoral training in the area of Muscle Physiology and Biomechanics at the Department of Physiology at the University of Kentucky’s College of Medicine.
During his 12+ years of research experience at the University of Kentucky, Dr. Mitov worked on numerous self-lead and collaborative projects involving various human diseases – heart failure, diabetic cardiovascular complications, aging, cancer and others. He had the privilege to train and mentor undergraduate, graduate and medical students, postdocs, residents and staff members helping them achieve their career goals. Dr. Mitov has several publications and serves as an editorial board member and reviewer of scientific journals.
Prior to joining SHSU-COM, Dr. Mitov was founding faculty at ICOM and has 7+ years of experience of doing research in osteopathic medical school environment and mentored more then 35 students over the years. Additionally, Dr. Mitov has outstanding benchtop research skills, he played a critical role in establishing, managing and supervising the daily operations at a unique core facility at the NCI-designated Markey Cancer Center at the University of Kentucky. He provided consultations and research services for investigators interested in cellular bioenergetics using Seahorse Flux technology, free radical biology and oxidative stress metabolism.
| Muscle biology |
| Mitochondrial dysfunction |
| Oxidative stress |
| Thermal biology |
| Cancer and Diabetes |
| Neurodegenerative diseases |
Published in: Cells, JBC, Transplantation, Experimental Cell Research, Cell Death and Disease, International Journal of Pharmaceutics, Biomaterials, Oncotarget, etc.
Funded Awards: ICOM Research Seed Project: “Adaptations of aging muscle to low-intensity vibration (LIV)” (Project budget: $15,000, Role: PI); American Heart Association/Postdoc Fellowship AHA 09POST2230406 – Project Title: “Gender-specific mechanisms leading to elevated myocardial stiffness in type I diabetes” ($88,000 for salary support; Role: Postdoctoral fellow);
Honors: NBOME National Faculty – item writer and reviewer for COMLEX Level 1, 2 & 3; ICOM Career Achievement Award – inaugural recipient of the ICOM career achievement award (for 5 years of employee service in teaching, service, and research at ICOM); American Physiological Society Research Career Enhancement Award – a highly competitive award designed to enhance the career potential of APS regular faculty members (up to $20,000 for research project expansion).
Complete list of scholarly output at: https://orcid.org/0000-0001-9101-5053
Google Scholar: https://scholar.google.com/citations?hl=en&user=r3W-M9AAAAAJ
Citations: 1309
H-index: 17
Mitov, MI (2024). Endocrine Functions of the Adipose Tissue. In: Avtanski, D. (eds) Adipose Tissue. Contemporary Endocrinology. Springer, Cham. https://doi.org/10.1007/978-3-031-72570-8_4
Gedaly R, De Stefano F, Turcios L, Hill M, Hidalgo G, Mitov MI, Alstott MC, Butterfield DA, Mitchell HC, Hart J, Al-Attar A, Jennings CD, Marti F. (2019). mTOR Inhibitor Everolimus in Regulatory T Cell Expansion for Clinical Application in Transplantation. Transplantation, 2019 Apr;103(4):705-715. https://doi.org/10.1097/tp.0000000000002495
Mitov MI, Harris JW, Alstott MC, Zaytseva YY, Evers BM, Butterfield DA. (2017). Temperature induces significant changes in both glycolytic reserve and mitochondrial spare respiratory capacity in colorectal cancer cell lines. Experimental Cell Research 2017, May 15th; 354(2): 112-121. https://doi.org/10.1016/j.yexcr.2017.03.046
Zhao Y, Miriyala S, Miao L, Mitov MI, Schnell D, Dhar S, Sultana R, Butterfield DA, St. Clair DK. (2014). Redox Proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after Doxorubicin treatment. Free Radical Biology and Medicine 2014 Jul; 72:55-65. https://doi.org/10.1016/j.freeradbiomed.2014.03.001
Mitov MI, Holbrook AM & Campbell KS. (2009). Myocardial short-range force responses increase with age in F344 rats. Journal of Molecular and Cellular Cardiology 2009, 46, 39-46. https://doi.org/10.1016/j.yjmcc.2008.10.004
I am open to all students that want to get involved in research. I do not discriminate based on previous experience, or any other factor. My only expectation is that students maintain good academic standing (do not fail any classes) while working with me on research projects.
The research I am currently involved in includes:
1) Changes in muscle sarcomere, oxidative stress, and extracellular proteins due to spinal cord injury in rats (collaboration with Idaho State University). Consistent with previous research, we hypothesized that spinal-transected rats will have reduced hindlimb muscle mass compared to sham-control rats. However, we predict the difference will not be as much reduced as seen in adults due to the amount of limb activity observed in neonatal spinal injury previously in ISU. We will quantify the changes in thick & thin filament muscle proteins and study how these correlate with denervation (i.e., spinal cord injury), sex differences, and age effects.
2) Changes in cellular bioenergetics, oxidative stress, and insulin signaling in various cancer, pancreatic cell lines, and mice exposed to hypo- and hyperthermia conditions (collaboration with Boise State University). Cellular bioenergetics (broadly defined investigation of the function of mitochondria and glycolysis in energy production) plays an essential role in many pathophysiological conditions. It is well recognized that disturbances in cellular bioenergetics represent some of the most distinct factors involved in the development and progression of cancer and diabetes. This project will investigate the therapeutic potential of various naturally occurring antioxidant compounds such as melatonin, cortisol, apigenin, and others for resting the disturbance in cellular bioenergetics and ultimately aiming to improve the quality of life of cancer or diabetes patients. Additionally, we will investigate how environmental factors (temperature, pH, and phosphate levels) at cellular levels could be manipulated to possibly restore (or enhance) bioenergetic profiles of dysfunctional cells. We will utilize an in vitro model to study bioenergetics of normal and dysfunctional pancreatic β-cell and lung fibroblast/lung cancer cell lines.
3) Utilize proteomics and transcriptomics to decipher the effects of low-intensity vibrations on restoring muscle mass and function in mice models of aging and cachexia (collaboration with Boise State University). Weight-lifting and other strenuous exercises are recognized as countermeasures against musculoskeletal aging and have been shown to attenuate age-related decreases in muscle mass, force, and regenerative capacity. Exercise could slow or prevent impairments in both bone and muscle metabolism. However, not all elderly individuals or patients with bone or muscle mass loss could engage in such activities (weight-lifting or other strenuous exercises) due to various health factors or preexisting conditions. Our central hypothesis is that the primary component of exercise, the mechanical signals, when applied in the form of low-intensity vibration (LIV), could delay or reverse the age-related sarcopenia. The proposed study plan will use mouse skeletal (quadriceps muscles) samples collected as a byproduct of Dr. Uzer R01 bone low-intensity vibration (LIV) project. Most of the tissues and data is already collected, need student to help with bioinformatics, gel electrophoresis for sarcomeirc proteins and analysis of oxidative stress by slot blots for protein carbonyls, 3-nitortyrosine and 4-hydroxy 2-nonenal (biomarkers of oxidative stress).
4)Investigation of the effects of holistic and physically demanding movement programs on body schema, mental health, and the love of movement among freshmen and sophomore medical students. Additionally, we will examine potential mechanisms regarding how holistic movement affects health. This research is in collaboration with Dr. Maria Kosma from LSU and partially, it is based on Merleau-Ponty’s concept of embodiment (body-mind unison).
Petra Rocic, PhD
https://orcid.org/0000-0002-5781-3075
Dr. Rocic’s research focus is in the area of cardiovascular complications of obesity, type II diabetes and metabolic syndrome. She is particularly interested in myocardial adaptations to transient, repetitive ischemia characteristic of stable angina pectoris, acute ischemia with reperfusion injury that occurs with myocardial infarction, and chronic ischemia associated with heart failure, and how adaptive processes to these conditions are further impaired in patients with the aforementioned risk factors resulting in earlier and greater morbidity and mortality. Currently Dr. Rocic’s lab is working on 20-HETE, a pro-inflammatory cytochrome P450 (CYP) product of arachidonic acid metabolism, which may represent a promising target for pharmacological therapy aimed at reducing infarct size and incidence of heart failure after myocardial infarction in metabolic syndrome patients. In addition, the lab is exploring whether there is a link between elevated plasma 20-HETE levels and the severity of Covid-19, development of the post-Covid-19 syndrome or the robustness of the host antibody-mediated immune response against SARS-Cov2.
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Myocardial ischemia |
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Heart failure |
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Cardiovascular |
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Published in: Arteriosclerosis, Thrombosis and Vascular Biology Editorial board member for: Circulation Research, 2012-2020 Funded Awards: NIH, Mechanistic Basis of miR-145-mediated Restoration of Coronary Collateral Growth, 2015-2020 Honors: Red Sash Teaching Award, University of South Alabama, 2012 and 2013 Complete list of scholarly output at: |
Citations: 3343 H-index: 27 Citations: 3414 H-index: 25 |
Hutcheson R, Terry R, Chaplin J, Smith E, Musiyenko A, Russell JC, Lincoln T, Rocic P. MicroRNA-145 restores contractile vascular smooth muscle phenotype and coronary collateral growth in the metabolic syndrome. Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):727-36. doi: 10.1161/ATVBAHA.112.301116.
Reed R, Kolz C, Potter B, Rocic P. The mechanistic basis for the disparate effects of angiotensin II on coronary collateral growth. Arterioscler Thromb Vasc Biol. 2008 Jan;28(1):61-7. doi: 10.1161/ATVBAHA.107.154294.
Joseph G, Soler A, Hutcheson R, Hunter I, Bradford C, Hutcheson B, Gotlinger KH, Jiang H, Falck JR, Proctor S, Schwartzman ML, Rocic P. Elevated 20-HETE impairs coronary collateral growth in metabolic syndrome via endothelial dysfunction. Am J Physiol Heart Circ Physiol. 2017 Mar 1;312(3):H528-H540. doi: 10.1152/ajpheart.00561.2016.
Signorelli SS, Vanella L, Abraham NG, Scuto S, Marino E, Rocic P. Pathophysiology of chronic peripheral ischemia: new perspectives. Ther Adv Chronic Dis. 2020 Feb 5;11:2040622319894466. doi: 10.1177/2040622319894466.
Rocic P, Schwartzman ML. 20-HETE in the regulation of vascular and cardiac function. Pharmacol Ther. 2018 Dec;192:74-87. doi: 10.1016/j.pharmthera.2018.07.004.
Hunter I, Soler A, Joseph G, Hutcheson B, Bradford C, Zhang FF, Potter B, Proctor S, Rocic P. Cardiovascular function in male and female JCR:LA-cp rats: effect of high-fat/high-sucrose diet. Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H742-H751. doi: 10.1152/ajpheart.00535.2016.
Project 1: Plasma Levels of 20-HETE in Patients Diagnosed with COVID-19.
A proinflammatory eicosanoid, 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) has recently emerged as a potential biomarker, with high plasma levels positively correlating with poor outcomes in patients with coronary events. Whether predictive value of 20-HETE extends to patients with other inflammatory conditions is unknown. The aims of this project are to determine whether 20-HETE levels are elevated during active SARS-CoV-2 infection and whether elevated levels positively correlate with development pf severe Covid-19 disease and/or post-Covid-19 syndrome and/or inability to develop long-term immunity (low anti-SARS-Cov-2 IgG levels).
Sahar Soliman Rph, PhD https://orcid.org/0000-0002-0648-0979
Dr. Soliman’s translational research training focused on angiogenesis and the neurovascular unit, with an emphasis on repurposing FDA-approved drugs in stroke therapeutics. During her postdoctoral training, she studied the pathogenesis of intraventricular hemorrhage as a complication of prematurity. Her pharmacy training and her passion to promote safe medication practices in rural and underserved areas led her to conduct rural health-centered research studying the opioid crisis in East Texas. Dr. Soliman is conducting her research with a multidisciplinary team from the College of Osteopathic Medicine and Sam Houston State University. Future research in this field includes studying the effect of COVID-19 pandemic on the existing opioid epidemic in East Texas.
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Pharmacogenetics |
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Translational research |
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Cardiovascular |
| Stroke |
| Opioids |
Research Highlights |
Impact Metrics |
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Published in: Journal of Pharmacology and Experimental Therapeutics Funded Awards: SHSU, Investigating the Effect of COVID-19 Pandemic on the Opioid Epidemic in Rural east Texas, 2020-2023, (Principal Investigator) AHA, Mechanisms of Vascular Protection of Angiotensin Receptor Blockade after Stroke, 2012-2014, (Principal Investigator) Honors: American Heart Association Pre-doctoral Fellowship, 2012 – 2014, Score: 1.4, Percentile rank: 4.9% Moderated Poster, 2012, International Stroke Conference, New Orleans, LA.
Complete list of scholarly output at: |
Citations: 465 H-index: 10 Citations: 352 H-index: 11
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Alhusban A, Fouda AY, Bindu Pillai, Ishrat T, Soliman S, Fagan SC. Compound 21 is pro-angiogenic in the brain and results in sustained recovery after ischemic stroke. J Hypertens. 2015 Jan;33(1):170-80. doi: 10.1097/HJH.0000000000000364.
Soliman S, Ishrat T, Pillai A, Somanath PR, Ergul A, El-Remessy AB, Fagan SC. Candesartan induces a prolonged proangiogenic effect and augments endothelium-mediated neuroprotection after oxygen and glucose deprivation: role of vascular endothelial growth factors A and B. J Pharmacol Exp Ther. 2014 Jun;349(3):444-57. doi: 10.1124/jpet.113.212613.
Ishrat T, Soliman S, Eldahshan W, Pillai B, Ergul A, Fagan SC. Silencing VEGF-B Diminishes the Neuroprotective Effect of Candesartan Treatment After Experimental Focal Cerebral Ischemia. Neurochem Res. 2018 Oct;43(10):1869-1878. doi: 10.1007/s11064-018-2604-x.
Soliman S, Ishrat T, Fouda AY, Patel A, Pillai B, Fagan SC. Sequential Therapy with Minocycline and Candesartan Improves Long-Term Recovery After Experimental Stroke. Transl Stroke Res. 2015 Aug;6(4):309-22. doi: 10.1007/s12975-015-0408-8.
Alhusban A, Fouda AY, Bindu Pillai, Ishrat T, Soliman S, Fagan SC. Compound 21 is pro-angiogenic in the brain and results in sustained recovery after ischemic stroke. J Hypertens. 2015 Jan;33(1):170-80. doi: 10.1097/HJH.0000000000000364.
Project 1: Trends in Opioid Prescribing in East Texas.
Opioid epidemic is a major public health problem in the United States. The widespread misuse of prescription opioids has been a major contributor to the opioid crisis. The aim of this project is to analyze opioid prescribing rates and trends in our service area, East Texas, in order to more effectively address the opioid crisis.
Project 2: Impact of Health Determinants on the Opioid in East Texas.
This rural-health centered research aims at analyzing the impact of health determinants on the opioid crisis in East Texas. Completion of this project will help identify patients at highest risk of developing opioid use disorder (OUD).
Project 3: Investigating the Effect of COVID-19 Pandemic on Opioid Epidemic in Rural East Texas.
The emergence of COVID-19 epidemic and the emotional toll, imposed by social isolation, unemployment and anxiety, is likely to worsen opioid crisis in rural communities of East Texas, aggravated by the limited access to healthcare. This project aims at analyzing opioid prescribing and dispensing patterns during the COVID-19 outbreak, with the overarching goal of enhancing rural health and reducing rural health disparities.
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